Views: 1 Author: Site Editor Publish Time: 2022-01-22 Origin: Site
Hydroxypropyl methyl cellulose HPMC is used to manufacture eye drops, and includes the following steps: first, in the following parts by weight selected raw materials, hydroxypropyl methyl cellulose HPMC in 3 pieces, 40 ℃ to 70 ℃ in the water for injection in 300-800, to add the hydroxypropyl methyl cellulose HPMC to the above the water, over and over 30 minutes, after completely evenly spread out, adopting low temperature preservation, confirmed The storage temperature is controlled at 0℃-30℃, stored for more than 12 hours, can be used; Then take 150 parts by weight of water for injection to dissolve other raw and auxiliary materials of eye drops, and mix them evenly with the prepared hydroxypropyl methyl cellulose HPMC solution at room temperature. Finally, add water to the mixture solution until the mass/volume ratio concentration of hydroxypropyl methyl cellulose HPMC is 0.3%, and stir evenly to obtain the finished eye drops. The invention can obtain hydroxypropyl methyl cellulose HPMC solution with maximum viscosity and clarity, solve the problem of precipitation of the final eye drop product, and improve the quality of the product.
Formula of eye drops
The weight percentage concentration of each component of eye drops was: povidone iodine 0.1% ~ 0.5%, lidocaine 0.5% ~ 1%, hydroxypropyl methyl cellulose HPMC 0.5% ~ 1.5%, flumeilon 0.05% ~ 0.15%, sodium hyaluronate 0.05% ~ 0.15%. Preparation methods are described, with distilled water respectively first povidone iodine, lidocaine, fluorine dragon, hydroxypropyl methyl cellulose, sodium hyaluronate made from dissolving povidone iodine solution, lidocaine solution, fluorine dragon solution, hydroxypropyl methyl cellulose solution, sodium hyaluronate solution, then povidone iodine solution, lidocaine solution, fluorine dragon solution and/or and hydroxypropyl methyl cellulose solution / or sodium hyaluronate solution is mixed to form a mixed solution after the preparation of eye drops. The invention greatly broadens the wide spectrum of eye drops and reduces the irritation to the cornea.