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HPMC For Medicine

Views: 2     Author: Site Editor     Publish Time: 2022-01-22      Origin: Site

HPMC for medicine has become one of the largest amount of health care and pharmaceutical excipients at home and abroad, because HPMC for medicine has the advantages that other excipients do not have.

1. Water solubility

HPMC for medicine is soluble in cold water below 40 ℃ or 70% ethanol. It is basically insoluble in hot water above 60 ℃, but it can be gelated.

2. Chemical inertia

HPMC for medicine belongs to a non-ionic cellulose ether, its solution does not have ionic charge and metal salts or ionic organic compounds, so in the preparation of production process, other excipients do not react with it.

3. Stability

It is stable to both acid and base, and can be stored in the range of P H 3 ~ 11 for a long time without obvious change in viscosity. HPMC aqueous solution has mildew resistance and can keep good viscosity stability in long-term storage. Pharmaceutical excipients using HPMC for medicine, its quality stability than the use of traditional excipients (such as dextrin, starch, etc.) is better.

4. Adjustable viscosity

HPMC derivatives of different viscosity can be matched in accordance with different proportions, its viscosity can change in accordance with certain rules, and has a good linear relationship, so it can be selected according to the needs of the ratio. 2. 5 metabolic inertia HPMC is not absorbed in the body is not metabolized, does not provide heat, so it is a safe pharmaceutical preparation excipients. .

5. Security

HPMC for medicine is generally considered non-toxic and non-irritating material.

Hydroxypropyl methyl cellulose (HPMC) is an cellulose ether produced by the reaction of chloromethane and propylene oxide with basic cellulose. White or almost white fiber or granular powder, odorless. It has been applied in the pharmaceutical industry for more than 40 years, and has been adopted in USP19 edition and Chinese Pharmacopoeia 1990 edition. It has achieved good results in film coating materials and adhesive applications.

Pharmaceutical grade HPMC hydroxypropyl methyl cellulose has high requirements on raw materials, production technology and product quality. In recent years, under the influence of increasingly strict environmental protection policies, some small pharmaceutical auxiliary materials enterprises in East China have even withdrawn from the market, and the pharmaceutical grade HPMC hydroxypropyl methyl cellulose for medicine industry has also been affected, some small-scale production capacity has withdrawn, and the capacity concentration has been improved.